Name: Elubrixin tosylate
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT214324208
Cas No:960495-43-6
常用名:Elubrixin tosylate
别名:SB-656933 tosylate, Elubrixin tosylate
IUPAC:1-[4-chloro-2-hydroxy-3-(piperazine-1-sulfonyl)phenyl]-3-(2-chloro-3-fluorophenyl)urea; 4-methylbenzene-1-sulfonic acid
IUPAC:1-[4-chloro-2-hydroxy-3-(piperazine-1-sulfonyl)phenyl]-3-(2-chloro-3-fluorophenyl)urea; 4-methylbenzene-1-sulfonic acid
InChI key:CJAUWWGOABMMJX-UHFFFAOYSA-N

分子式:C24H25Cl2FN4O7S2
分子量:635.5
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cc1ccc(cc1)S(O)(=O)=O.Oc1c(NC(=O)Nc2cccc(F)c2Cl)ccc(Cl)c1S(=O)(=O)N1CCNCC1
SMILES:Cc1ccc(cc1)S(O)(=O)=O.Oc1c(NC(=O)Nc2cccc(F)c2Cl)ccc(Cl)c1S(=O)(=O)N1CCNCC1

Elubrixin tosylate (SB-656933 tosylate) is a high-potency, selective, competitive, and reversible CXCR2 antagonist, as well as an antagonist of the IL-8 receptor. It effectively inhibits upregulation of neutrophil CD11b (with an IC50 of 260.7 nM) and shape change (with an IC50 of 310.5 nM). This compound holds promise for the study of inflammatory diseases, including inflammatory bowel disease and airway inflammation.

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