Name: FC 11
Rating: 5 (10 reviews)

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结构编辑

类似物检索

HIT ID:HIT214324223
Cas No:2271035-37-9
常用名:FC 11
IUPAC:1-{2-[2-(2-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}ethoxy)ethoxy]ethyl}-N-(4-{[4-({[2-(N-methylmethanesulfonamido)pyridin-3-yl]methyl}amino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1H-1,2,3-triazole-4-carboxamide
IUPAC:1-{2-[2-(2-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}ethoxy)ethoxy]ethyl}-N-(4-{[4-({[2-(N-methylmethanesulfonamido)pyridin-3-yl]methyl}amino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1H-1,2,3-triazole-4-carboxamide
InChI key:RZKZQCHSKWKOAJ-UHFFFAOYSA-N

分子式:C41H42F3N13O9S
分子量:949.92
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CN(c1ncccc1CNc1nc(Nc2ccc(NC(=O)c3cn(CCOCCOCCNc4cccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c45)nn3)cc2)ncc1C(F)(F)F)S(C)(=O)=O
SMILES:CN(c1ncccc1CNc1nc(Nc2ccc(NC(=O)c3cn(CCOCCOCCNc4cccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c45)nn3)cc2)ncc1C(F)(F)F)S(C)(=O)=O

FC 11 is a highly potent focal adhesion Ki nase (FAK) PROTAC®Degrader (DC50 values are 40 to 370 pM depending on cell line), which is composed of the FAK inhibitor PF 562217 joined by a linker to the cereblon-binding ligand Pomalidomide. The effects of FC 11 are reversible upon compound wash out. FC 11 also degrades autophosphorylated FAK (pFAKtyr397), displaying near complete degradation after 3 hours at 100 nM in TM3 cells.

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