Name: AY 254
Rating: 5 (10 reviews)

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HIT ID:HIT214324243
Cas No:2093408-03-6
常用名:AY 254
IUPAC:(2S)-5-carbamimidamido-2-[(2S)-2-[(2S)-2-cyclohexyl-2-[(2S)-3-cyclohexyl-2-[(1,2-oxazol-5-yl)formamido]propanamido]acetamido]propanamido]pentanamide
IUPAC:(2S)-5-carbamimidamido-2-[(2S)-2-[(2S)-2-cyclohexyl-2-[(2S)-3-cyclohexyl-2-[(1,2-oxazol-5-yl)formamido]propanamido]acetamido]propanamido]pentanamide
InChI key:ZVDSAIOSGOWYAW-CKLTXHEASA-N

分子式:C30H49N9O6
分子量:631.779
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccno1)C1CCCCC1)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O |@@:25|
SMILES:C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccno1)C1CCCCC1)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O |@@:25|

AY 254 is a potent PAR2 biased agonist. Selectively activates ERK1/2 signaling (EC50= 2 nM for ERK1/2 phosphorylation versus 80 nM for Ca2+release). Reduces cytoKi ne-induced caspase 3/8 activation, promotes scratch-wound healing, and induces IL-8 secretion, in human colorectal cancer (HT29) cellsin vitro.

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