Name: FTI 277 TFA
Rating: 5 (10 reviews)

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HIT ID:HIT214324253
Cas No:1217447-06-7
常用名:FTI 277 TFA
IUPAC:methyl (2S)-2-[(5-{[(2R)-2-amino-3-sulfanylpropyl]amino}-[1,1'-biphenyl]-2-yl)formamido]-4-(methylsulfanyl)butanoate; trifluoroacetic acid
IUPAC:methyl (2S)-2-[(5-{[(2R)-2-amino-3-sulfanylpropyl]amino}-[1,1'-biphenyl]-2-yl)formamido]-4-(methylsulfanyl)butanoate; trifluoroacetic acid
InChI key:GJEFFRDWFVSCOJ-PXPMWPIZSA-N

分子式:C24H30F3N3O5S2
分子量:561.64
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:OC(=O)C(F)(F)F.COC(=O)[C@H](CCSC)NC(=O)c1ccc(NC[C@@H](N)CS)cc1-c1ccccc1
SMILES:OC(=O)C(F)(F)F.COC(=O)[C@H](CCSC)NC(=O)c1ccc(NC[C@@H](N)CS)cc1-c1ccccc1

FTI 277 TFA is a prodrug form of FTI 276 that inhibits farnesyltransferase (FTase) (IC50 = 0.5 nM). Inhibits H-Ras and K-Ras processing in whole cells (IC50 values are 0.1 and 10μM respectively) and disrupts constitutive H-Ras-specific activation of MAPK. Causes significant antiproliferative effects in human malignant glioma cells and many other tumor cell lines.

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