Name: Rp-8-bromo-Cyclic AMPS (sodium salt)
Rating: 5 (10 reviews)

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HIT ID:HIT214390561
Cas No:925456-59-3
常用名:Rp-8-bromo-Cyclic AMPS (sodium salt)
常用名:Rp-8-bromo-Cyclic AMPS (sodium salt)
IUPAC:sodium (4aR,6R,7R,7aS)-6-(6-amino-8-bromo-9H-purin-9-yl)-7-hydroxy-2-sulfanylidene-hexahydro-2lambda5-furo[3,2-d][1,3,2]dioxaphosphinin-2-olate
IUPAC:sodium (4aR,6R,7R,7aS)-6-(6-amino-8-bromo-9H-purin-9-yl)-7-hydroxy-2-sulfanylidene-hexahydro-2lambda5-furo[3,2-d][1,3,2]dioxaphosphinin-2-olate
InChI key:SKJLJCVVXRNYGJ-QKAIHBBZSA-M

分子式:C10H10BrN5NaO5PS
分子量:446.15
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[Na+].Nc1ncnc2n([C@@H]3O[C@@H]4COP([O-])(=S)O[C@H]4[C@H]3O)c(Br)nc12
SMILES:[Na+].Nc1ncnc2n([C@@H]3O[C@@H]4COP([O-])(=S)O[C@H]4[C@H]3O)c(Br)nc12

Rp-8-bromo-Cyclic AMPS (Rp-8-bromo-cAMPS) is a cell-permeable cAMP analog that combines an exocyclic sulfur substitution in the equatorial position of the cyclophosphate ring with a bromine substitution in the adenine base of cAMP. It acts as an antagonist of cAMP-dependent protein kinases (PKAs) and is resistant to hydrolysis by cyclic nucleotide phosphodiesterases. Rp-8-bromo-cAMPS more effectively antagonizes cAMP-dependent activation of purified PKA type I from rabbit muscle than PKA type II from bovine heart.

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