Name: Rp-8-CPT-cAMPS
Rating: 5 (10 reviews)

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类似物检索

HIT ID:HIT214390565
Cas No:129735-01-9
常用名:Rp-8-CPT-cAMPS
IUPAC:(2R,4aR,6R,7R,7aS)-6-{6-amino-8-[(4-chlorophenyl)sulfanyl]-9H-purin-9-yl}-7-hydroxy-2-sulfanyl-hexahydro-2lambda5-furo[3,2-d][1,3,2]dioxaphosphinin-2-one
IUPAC:(2R,4aR,6R,7R,7aS)-6-{6-amino-8-[(4-chlorophenyl)sulfanyl]-9H-purin-9-yl}-7-hydroxy-2-sulfanyl-hexahydro-2lambda5-furo[3,2-d][1,3,2]dioxaphosphinin-2-one
InChI key:IVNQJYQKSYRLTE-FUWBYEKLSA-N

分子式:C16H15ClN5O5PS2
分子量:487.87
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Nc1ncnc2n([C@@H]3O[C@@H]4CO[P@](S)(=O)O[C@H]4[C@H]3O)c(Sc3ccc(Cl)cc3)nc12
SMILES:Nc1ncnc2n([C@@H]3O[C@@H]4CO[P@](S)(=O)O[C@H]4[C@H]3O)c(Sc3ccc(Cl)cc3)nc12

Rp-8-CPT-cAMPS is a powerful and competitive antagonist of cAMP-induced activation of cAMP-dependent protein kinase (PKA) I and II. Acting as a potent cAMP analog, Rp-8-CPT-cAMPS exhibits a preference for site A of RI over site A of RII. Additionally, it favors site B of RII over site B of RI. This compound effectively inhibits cAMP-dependent PKA activation and demonstrates selectivity in binding to specific sites within the protein kinase.

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