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  3. HIT214391058
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HIT214391058
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HIT214391058
  • HIT ID:HIT214391058
  • Cas No:1333468-05-5;2751721-40-9
  • 常用名:AZ5576
  • IUPAC:(1S,3R)-3-acetamido-N-[4-(4-fluoro-2-methoxyphenyl)pyridin-2-yl]cyclohexane-1-carboxamide
    IUPAC:(1S,3R)-3-acetamido-N-[4-(4-fluoro-2-methoxyphenyl)pyridin-2-yl]cyclohexane-1-carboxamide
  • InChI key:QNWXRLPZIFMTBK-DOTOQJQBSA-N
  • 分子式:C21H24FN3O3
  • 分子量:385.439
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:COc1cc(F)ccc1-c1ccnc(NC(=O)[C@H]2CCC[C@H](C2)NC(C)=O)c1 |lp:1:2,5:3,12:1,14:1,16:2,23:1,26:2|
    SMILES:COc1cc(F)ccc1-c1ccnc(NC(=O)[C@H]2CCC[C@H](C2)NC(C)=O)c1 |lp:1:2,5:3,12:1,14:1,16:2,23:1,26:2|
  • AZ5576 racemate is a racemic mixture of AZ5576 isomers. AZ5576 is a potent, highly selective, and orally bioavailable inhibitor of Cdk9 that inhibits Cdk9 enzyme activity with an IC50 <5nM and decreases phosphorlyation of Ser2-RNAPII in cells with an IC50 of 96nM. In the MLL-fusion containing acute myeloid leukemia (AML) line, MV411, short-term treatment with AZ5576 led to a rapid dose-dependent decrease in pSer2-RNAPII with concomitant loss of Mcl1 mRNA and protein, resulting in the cleavage and activation of caspase 3 and loss of cell viability.
市场产品/服务共显示2个结果
  • 供应商
    TargetMolSC
    规格
    货期
    1-3天
    纯度
    99.88%
    ¥ 297.00
    1
  • 供应商
    TargetMolSC
    规格
    货期
    1-2周
    纯度
    -
    ¥ 10,600.00
    1

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