Name: Salinomycin
Rating: 5 (10 reviews)

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结构编辑

类似物检索

HIT ID:HIT214432333
Cas No:53003-10-4
常用名:Salinomycin
别名:盐霉素, Procoxacin
IUPAC:(2R)-2-[(5S)-6-[(2S,3S,4S,6R)-6-[(2S,5S,7R,10S,12R,15R)-2-[(5R,6S)-5-ethyl-5-hydroxy-6-methyloxan-2-yl]-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5^{7}.3^{5}]pentadec-13-en-9-yl]-3-hydroxy-4-methyl-5-oxooctan-2-yl]-5-methyloxan-2-yl]butanoic acid
IUPAC:(2R)-2-[(5S)-6-[(2S,3S,4S,6R)-6-[(2S,5S,7R,10S,12R,15R)-2-[(5R,6S)-5-ethyl-5-hydroxy-6-methyloxan-2-yl]-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5^{7}.3^{5}]pentadec-13-en-9-yl]-3-hydroxy-4-methyl-5-oxooctan-2-yl]-5-methyloxan-2-yl]butanoic acid
InChI key:KQXDHUJYNAXLNZ-DLOCPGDYSA-N

分子式:C42H70O11
分子量:751.011
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CC[C@H](C1CC[C@H](C)C(O1)[C@@H](C)[C@H](O)[C@H](C)C(=O)[C@H](CC)C1O[C@@]2(O[C@@]3(CC[C@](C)(O3)C3CC[C@](O)(CC)[C@H](C)O3)[C@H](O)C=C2)[C@H](C)C[C@@H]1C)C(O)=O
SMILES:CC[C@H](C1CC[C@H](C)C(O1)[C@@H](C)[C@H](O)[C@H](C)C(=O)[C@H](CC)C1O[C@@]2(O[C@@]3(CC[C@](C)(O3)C3CC[C@](O)(CC)[C@H](C)O3)[C@H](O)C=C2)[C@H](C)C[C@@H]1C)C(O)=O

Salinomycin (Procoxacin), a polyether potassium ionophore antibiotic, specifically inhibits the growth of gram-positive bacteria. It acts as a potent inhibitor of Wnt/β-catenin signaling, blocking Wnt-induced LRP6 phosphorylation. Additionally, Salinomycin (Procoxacin) demonstrates selective activity against human cancer stem cells.

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