Name: dCBP-1
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT214432571
Cas No:2484739-25-3
常用名:dCBP-1
IUPAC:3-[7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydroquinolin-1-yl]-1-[1-(1-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl]amino}-3,6,9,12-tetraoxapentadecanoyl)piperidin-4-yl]-N-methyl-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridine-5-carboxamide
IUPAC:3-[7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydroquinolin-1-yl]-1-[1-(1-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl]amino}-3,6,9,12-tetraoxapentadecanoyl)piperidin-4-yl]-N-methyl-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridine-5-carboxamide
InChI key:ILVRLRGBSSFKIE-UHFFFAOYSA-N

分子式:C51H63F2N11O10
分子量:1028.129
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CNC(=O)N1CCc2c(C1)c(nn2C1CCN(CC1)C(=O)CCOCCOCCOCCOCCNc1ccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c2c1)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F
SMILES:CNC(=O)N1CCc2c(C1)c(nn2C1CCN(CC1)C(=O)CCOCCOCCOCCOCCNc1ccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c2c1)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F

dCBP-1 是基于Cereblon 配体的p300/CBP 的选择性双功能降解剂。dCBP-1可以有效的杀死多发性骨髓瘤细胞，并降低驱动 MYC 表达的致癌增强子活性。

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