Name: AX-024
Rating: 5 (10 reviews)

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HIT ID:HIT214432914
Cas No:1370544-73-2
常用名:AX-024
IUPAC:1-{[4-(4-fluorophenyl)-6-methoxy-2H-chromen-3-yl]methyl}pyrrolidine
IUPAC:1-{[4-(4-fluorophenyl)-6-methoxy-2H-chromen-3-yl]methyl}pyrrolidine
InChI key:VMMKGVRPILDZML-UHFFFAOYSA-N

分子式:C21H22FNO2
分子量:339.41
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:COc1ccc2OCC(CN3CCCC3)=C(c3ccc(F)cc3)c2c1
SMILES:COc1ccc2OCC(CN3CCCC3)=C(c3ccc(F)cc3)c2c1

AX-024 is a novel chemical compound that acts as an orally available inhibitor of the TCR-Nck interaction. Its primary mechanism of action is the selective inhibition of T cell activation triggered by TCR stimulation. With an IC50 value of approximately 1 nM, AX-024 effectively modulates cell signaling by specifically targeting SH3 domains. Additionally, AX-024 demonstrates desirable characteristics such as low acute toxicity, high potency, and excellent selectivity. Notably, it exhibits strong inhibitory effects on the production of IL-6, TNF-α, IFN-γ, IL-10, and IL-17A.

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