Name: ATG7-IN-2
Rating: 5 (10 reviews)

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sdf 文件

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类似物检索

HIT ID:HIT214432954
Cas No:2226227-75-2
常用名:ATG7-IN-2
IUPAC:[(2R,3S,4R,5R)-5-{4-amino-3-methoxy-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3,4-dihydroxyoxolan-2-yl]methyl sulfamate
IUPAC:[(2R,3S,4R,5R)-5-{4-amino-3-methoxy-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-3,4-dihydroxyoxolan-2-yl]methyl sulfamate
InChI key:SVHOPJCSYNTLAH-RPKMEZRRSA-N

分子式:C11H16N6O7S
分子量:376.34
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:COc1nn([C@@H]2O[C@H](COS(N)(=O)=O)[C@@H](O)[C@H]2O)c2ncnc(N)c12
SMILES:COc1nn([C@@H]2O[C@H](COS(N)(=O)=O)[C@@H](O)[C@H]2O)c2ncnc(N)c12

ATG7-IN-2 (compound 1) is a highly potent inhibitor of the ATG7 protein, displaying an IC 50 value of 0.089 μM. This compound effectively suppresses the activity of autophagy marker LC3B, thereby regulating the autophagy process [1].

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