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  3. HIT214432974
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HIT214432974
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HIT214432974
  • HIT ID:HIT214432974
  • Cas No:2647464-92-2
  • 常用名:CXCR2 antagonist 3
  • IUPAC:1-(3-fluoro-2-methylphenyl)-3-(8-hydroxy-1,1-dioxo-2H-1lambda6-thiochromen-7-yl)urea
    IUPAC:1-(3-fluoro-2-methylphenyl)-3-(8-hydroxy-1,1-dioxo-2H-1lambda6-thiochromen-7-yl)urea
  • InChI key:HOMDQIYPTGGKMN-UHFFFAOYSA-N
  • 分子式:C17H15FN2O4S
  • 分子量:362.38
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:Cc1c(F)cccc1NC(=O)Nc1ccc2C=CCS(=O)(=O)c2c1O
    SMILES:Cc1c(F)cccc1NC(=O)Nc1ccc2C=CCS(=O)(=O)c2c1O
  • CXCR2 antagonist 3 (compound 11h) is a highly effective antagonist of CXC chemokine receptor 2 (CXCR2). It displays potent activity in inhibiting neutrophil infiltration into the air pouch, with double-digit nanomolar potencies against CXCR2. Moreover, CXCR2 antagonist 3 reduces the infiltration of neutrophils and MDSCs, while enhancing the infiltration of CD3+ T lymphocytes into Pan02 tumor tissues [1].
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    8-10周
    纯度
    -
    ¥ 14,900.00
    1

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