Name: Anticancer agent 57
Rating: 5 (10 reviews)

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HIT ID:HIT214433044
Cas No:2408017-71-8
常用名:Anticancer agent 57
IUPAC:(2E)-3-{4-[bis(2-chloroethyl)amino]phenyl}-1-(3-methoxyphenyl)prop-2-en-1-one
IUPAC:(2E)-3-{4-[bis(2-chloroethyl)amino]phenyl}-1-(3-methoxyphenyl)prop-2-en-1-one
InChI key:FDGNRFLWAKBGSV-JXMROGBWSA-N

分子式:C20H21Cl2NO2
分子量:378.29
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:COc1cccc(c1)C(=O)\C=C\c1ccc(cc1)N(CCCl)CCCl
SMILES:COc1cccc(c1)C(=O)\C=C\c1ccc(cc1)N(CCCl)CCCl

Anticancer agent 57 (compound 14) demonstrates potent inhibition of MDA-MB-231, MDA-MB-468, and MCF-7 cell lines, with IC 50 values ranging from 6.43 to 8.00 μM. Additionally, this agent induces cell cycle arrest and promotes apoptosis. In vivo studies using nude mice xenografted with MADMB-231 cells have shown that Anticancer agent 57 effectively inhibits tumor growth. Consequently, Anticancer agent 57 can serve as a valuable tool for researching triple negative breast cancer (TNBC) [1].

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