Name: PARP1-IN-10
Rating: 5 (10 reviews)

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HIT ID:HIT214433092
Cas No:2494001-21-5
常用名:PARP1-IN-10
IUPAC:1,3-dimethyl-5-({4-[2-oxo-2-(piperidin-1-yl)ethoxy]phenyl}methylidene)-1,3-diazinane-2,4,6-trione
IUPAC:1,3-dimethyl-5-({4-[2-oxo-2-(piperidin-1-yl)ethoxy]phenyl}methylidene)-1,3-diazinane-2,4,6-trione
InChI key:VKLCODKLVUQTBY-UHFFFAOYSA-N

分子式:C20H23N3O5
分子量:385.42
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CN1C(=O)N(C)C(=O)C(=Cc2ccc(OCC(=O)N3CCCCC3)cc2)C1=O
SMILES:CN1C(=O)N(C)C(=O)C(=Cc2ccc(OCC(=O)N3CCCCC3)cc2)C1=O

PARP1-IN-10 (compound 12c) is a highly potent and non-cytotoxic PARP1 inhibitor, displaying an in vitro IC50 value of 50.62 nM. This compound effectively induces cell cycle arrest at the G2/M phase and apoptosis, while also significantly augmenting the cytotoxic effects of temozolomide (TMZ) [1].

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