ASK1-IN-3 | CAS 2426705-19-1 | AnyMole

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HIT214433424

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HIT214433424

HIT ID:HIT214433424
Cas No:2426705-19-1
常用名:ASK1-IN-3
IUPAC:1-(6-{4-[(2R)-1-hydroxypropan-2-yl]-4H-1,2,4-triazol-3-yl}pyridin-2-yl)-3-{pyrazolo[1,5-a]pyridin-2-yl}urea
IUPAC:1-(6-{4-[(2R)-1-hydroxypropan-2-yl]-4H-1,2,4-triazol-3-yl}pyridin-2-yl)-3-{pyrazolo[1,5-a]pyridin-2-yl}urea
InChI key:GSYUZRLLPWNNAL-GFCCVEGCSA-N

分子式:C18H18N8O2
分子量:378.396
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:C[C@H](CO)n1cnnc1-c1cccc(NC(=O)Nc2cc3ccccn3n2)n1
SMILES:C[C@H](CO)n1cnnc1-c1cccc(NC(=O)Nc2cc3ccccn3n2)n1

ASK1-IN-3 is a highly potent and selective inhibitor of ASK1 kinase, demonstrating an IC 50 of 33.8 nM. This compound also exhibits inhibitory effects on various cell cycle regulating kinases. ASK1-IN-3 showcases remarkable induction of apoptosis in HepG2 cancer cells and displays potent activity in arresting the cell cycle [1].

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TargetMolSC
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货期
6-8周
纯度
-
¥ 14,900.00
1

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