GSK2646264 | CAS 1398695-47-0 | AnyMole

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HIT214433425

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HIT214433425

HIT ID:HIT214433425
Cas No:1398695-47-0
常用名:GSK2646264
IUPAC:7-{2-methoxy-6-[(4-methylpyridin-2-yl)methoxy]phenyl}-2,3,4,5-tetrahydro-1H-3-benzazepine
IUPAC:7-{2-methoxy-6-[(4-methylpyridin-2-yl)methoxy]phenyl}-2,3,4,5-tetrahydro-1H-3-benzazepine
InChI key:KYANYGKXMNYFBX-UHFFFAOYSA-N

分子式:C24H26N2O2
分子量:374.484
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:COc1cccc(OCc2cc(C)ccn2)c1-c1ccc2CCNCCc2c1
SMILES:COc1cccc(OCc2cc(C)ccn2)c1-c1ccc2CCNCCc2c1

GSK2646264 (Compound 44) is a highly effective and specific inhibitor of spleen tyrosine kinase (SYK) with a pIC50 of 7.1. In addition to targeting SYK, GSK2646264 also inhibits several other kinases, including LCK, LRRK2, GSK3β, JAK2, VEGFR2, Aurora B, and Aurora A, with pIC50 values of 5.4, 5.4, 5.3, 5, 4.5, <4.6 and <4.3, respectively. Notably, GSK2646264 demonstrates skin penetrability, reaching both the epidermis and dermis [1].

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TargetMolSC
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货期
8-10周
纯度
-
¥ 18,995.00
1

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