Name: P2X7 receptor antagonist-2
Rating: 5 (10 reviews)

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HIT ID:HIT214433498
Cas No:851269-75-5
常用名:P2X7 receptor antagonist-2
IUPAC:1-benzyl-N-[(2,4-dichlorophenyl)methyl]-5-oxopyrrolidine-3-carboxamide
IUPAC:1-benzyl-N-[(2,4-dichlorophenyl)methyl]-5-oxopyrrolidine-3-carboxamide
InChI key:NBEOSAFVNPGHAS-UHFFFAOYSA-N

分子式:C19H18Cl2N2O2
分子量:377.27
氢键供体数 (HBD):1
氢键受体数 (HBA):2
LogP:4.504
SMILES:Clc1ccc(CNC(=O)C2CN(Cc3ccccc3)C(=O)C2)c(Cl)c1
SMILES:Clc1ccc(CNC(=O)C2CN(Cc3ccccc3)C(=O)C2)c(Cl)c1

P2X7 receptor antagonist-2 is a highly potent antagonist of the P2X7 receptor, exhibiting a pIC50 value range of 6.5-7.5. Its efficacy in combating neuroinflammation has been demonstrated [1].

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