Name: (R)-ND-336
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT214433511
Cas No:2252493-33-5
常用名:(R)-ND-336
IUPAC:1-[4-(4-{[(2R)-thiiran-2-yl]methanesulfonyl}phenoxy)phenyl]methanamine hydrochloride
IUPAC:1-[4-(4-{[(2R)-thiiran-2-yl]methanesulfonyl}phenoxy)phenyl]methanamine hydrochloride
InChI key:DRGIZFGSEKSFIC-XFULWGLBSA-N

分子式:C16H18ClNO3S2
分子量:371.89
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cl.NCc1ccc(Oc2ccc(cc2)S(=O)(=O)C[C@H]2CS2)cc1
SMILES:Cl.NCc1ccc(Oc2ccc(cc2)S(=O)(=O)C[C@H]2CS2)cc1

(R)-ND-336 is a highly potent and selective MMP-9 inhibitor, displaying a K i value of 19 nM. It also exhibits inhibitory activity against MMP-2 (K i = 127 nM) and MMP-14 (K i =119 nM). With its significant potential, (R)-ND-336 is being investigated in the field of diabetic foot ulcers (DFUs) research [1].

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