Name: FGFR-IN-7
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

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HIT ID:HIT214433544
Cas No:2488764-17-4
常用名:FGFR-IN-7
IUPAC:2-[(6-chloropyridazin-3-yl)oxy]-N-{1-[(2,2-difluorocyclopropyl)methyl]piperidin-4-yl}-N-methylacetamide
IUPAC:2-[(6-chloropyridazin-3-yl)oxy]-N-{1-[(2,2-difluorocyclopropyl)methyl]piperidin-4-yl}-N-methylacetamide
InChI key:IQVHMRPINAMBJU-UHFFFAOYSA-N

分子式:C16H21ClF2N4O2
分子量:374.82
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CN(C1CCN(CC2CC2(F)F)CC1)C(=O)COc1ccc(Cl)nn1
SMILES:CN(C1CCN(CC2CC2(F)F)CC1)C(=O)COc1ccc(Cl)nn1

FGFR-IN-7 (compound 17) is an orally active, potent FGFR modulator with the ability to penetrate the blood-brain barrier. It exhibits neuroprotective properties, enhancing brain exposure and decreasing the likelihood of phospholidosis. FGFR-IN-7 proves valuable for research on neurodegenerative diseases [1].

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