E6201 | CAS 603987-35-5 | AnyMole

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HIT214433683

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HIT214433683

HIT ID:HIT214433683
Cas No:603987-35-5
常用名:E6201
IUPAC:(3S,4R,5E,8S,9S,11E)-14-(ethylamino)-8,9,16-trihydroxy-3,4-dimethyl-3,4,7,8,9,10-hexahydro-1H-2-benzoxacyclotetradecine-1,7-dione
IUPAC:(3S,4R,5E,8S,9S,11E)-14-(ethylamino)-8,9,16-trihydroxy-3,4-dimethyl-3,4,7,8,9,10-hexahydro-1H-2-benzoxacyclotetradecine-1,7-dione
InChI key:MWUFVYLAWAXDHQ-SDJOUKTJSA-N

分子式:C21H27NO6
分子量:389.448
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CCNc1cc(O)c2c(c1)\C=C\C[C@H](O)[C@H](O)C(=O)\C=C\[C@@H](C)[C@H](C)OC2=O
SMILES:CCNc1cc(O)c2c(c1)\C=C\C[C@H](O)[C@H](O)C(=O)\C=C\[C@@H](C)[C@H](C)OC2=O

E6201 (ER-806201) is a potent dual kinase inhibitor targeting MEK1 and FLT3, inhibiting their activities in an ATP-competitive manner. It effectively suppresses MEK1-induced ERK2 phosphorylation (IC50 = 5.2 nM), MKK4-induced JNK phosphorylation (IC50 = 91 nM), and MKK6-induced p38 MAPK phosphorylation (IC50 = 19 nM). E6201 exhibits anti-tumor and anti-psoriasis effects [1] [2].

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供应商
TargetMolSC
规格
货期
10-14周
纯度
-
¥ 93,000.00
1

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