Name: hCAIX-IN-8
Rating: 5 (10 reviews)

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HIT ID:HIT214433842
Cas No:2414633-40-0
常用名:hCAIX-IN-8
IUPAC:(2E)-3-(3-methoxy-4-{[1-(3-nitrophenyl)-1H-1,2,3-triazol-4-yl]methoxy}phenyl)prop-2-enoic acid
IUPAC:(2E)-3-(3-methoxy-4-{[1-(3-nitrophenyl)-1H-1,2,3-triazol-4-yl]methoxy}phenyl)prop-2-enoic acid
InChI key:SRKGDLYYDIWTBU-SOFGYWHQSA-N

分子式:C19H16N4O6
分子量:396.359
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:COc1cc(\C=C\C(O)=O)ccc1OCc1cn(nn1)-c1cccc(c1)[N+]([O-])=O
SMILES:COc1cc(\C=C\C(O)=O)ccc1OCc1cn(nn1)-c1cccc(c1)[N+]([O-])=O

hCAIX-IN-8 (compound 7i) is a highly potent and selective inhibitor of hCAIX, demonstrating potent inhibitory activity against CAIX with an IC50 value of 0.024 μM. It also exhibits inhibitory activity against CAII and CAVA with IC50 values of 1.99 μM and 1.10 μM, respectively. Furthermore, hCAIX-IN-8 exhibits anti-proliferative effects and low toxicity. It effectively reduces the occurrence of epithelial-to-mesenchymal transitions and promotes apoptosis. Additionally, hCAIX-IN-8 effectively inhibits cell migration and colonization potential [1].

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