Name: CDK1/Cyc B-IN-1
Rating: 5 (10 reviews)

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HIT ID:HIT214433849
Cas No:2459916-56-2
常用名:CDK1/Cyc B-IN-1
IUPAC:7-chloro-3-(2,4-dimethoxyphenyl)-5-methyl-2H,3H-[1,3]thiazolo[4,5-d]pyrimidine-2-thione
IUPAC:7-chloro-3-(2,4-dimethoxyphenyl)-5-methyl-2H,3H-[1,3]thiazolo[4,5-d]pyrimidine-2-thione
InChI key:NNKYAHQQRCIKAG-UHFFFAOYSA-N

分子式:C14H12ClN3O2S2
分子量:353.84
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:COc1ccc(c(OC)c1)-n1c2nc(C)nc(Cl)c2sc1=S
SMILES:COc1ccc(c(OC)c1)-n1c2nc(C)nc(Cl)c2sc1=S

CDK1/Cyc B-IN-1 (Compound 5) is a potent inhibitor of the CDK1/Cyc B complex, demonstrating selectivity with an IC50 value of 97 nM. This compound induces apoptosis and G2/M cell cycle arrest, effectively halting cancer cell proliferation. Additionally, CDK1/Cyc B-IN-1 exhibits a wide-ranging cytotoxic effect on various cancer cell lines [1].

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