Name: Trk-IN-10
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT214434004
Cas No:2700265-61-6
常用名:Trk-IN-10
IUPAC:(8S,18R)-12-fluoro-8,18-dimethyl-9,20-dioxa-1,2,6,17,23-pentaazapentacyclo[19.3.1.0^{4,24}.0^{10,15}.0^{17,22}]pentacosa-2,4(24),10(15),11,13,21(25),22-heptaen-5-one
IUPAC:(8S,18R)-12-fluoro-8,18-dimethyl-9,20-dioxa-1,2,6,17,23-pentaazapentacyclo[19.3.1.0^{4,24}.0^{10,15}.0^{17,22}]pentacosa-2,4(24),10(15),11,13,21(25),22-heptaen-5-one
InChI key:RZRSOLZCLWVUTL-NEPJUHHUSA-N

分子式:C20H20FN5O3
分子量:397.41
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:C[C@@H]1COc2cn3ncc4C(=O)NC[C@H](C)Oc5cc(F)ccc5CN1c2nc34
SMILES:C[C@@H]1COc2cn3ncc4C(=O)NC[C@H](C)Oc5cc(F)ccc5CN1c2nc34

Trk-IN-10 (Compound 14j) is a highly effective inhibitor of TRK, with an IC50 of 0.86 nM against TrkA and 6.92 nM against TrkA G595R. As an RTK, Trk plays a crucial role as a drug target in solid tumors. Trk-IN-10 (IC50 = 350 nM against ALK) demonstrates superior selectivity in inhibiting Trk, which has potential implications for toxicity reduction [1].

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