Name: ATX inhibitor 15
Rating: 5 (10 reviews)

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HIT ID:HIT214434006
Cas No:2484811-52-9
常用名:ATX inhibitor 15
IUPAC:3-[5-(4-{[bis(2-hydroxyethyl)amino]methyl}-1,3-thiazol-2-yl)-1-ethyl-1H-indol-3-yl]-1-[(3-chloro-4-methoxyphenyl)methyl]urea
IUPAC:3-[5-(4-{[bis(2-hydroxyethyl)amino]methyl}-1,3-thiazol-2-yl)-1-ethyl-1H-indol-3-yl]-1-[(3-chloro-4-methoxyphenyl)methyl]urea
InChI key:VVRQIPXYZCQXAH-UHFFFAOYSA-N

分子式:C27H32ClN5O4S
分子量:558.09
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CCn1cc(NC(=O)NCc2ccc(OC)c(Cl)c2)c2cc(ccc12)-c1nc(CN(CCO)CCO)cs1
SMILES:CCn1cc(NC(=O)NCc2ccc(OC)c(Cl)c2)c2cc(ccc12)-c1nc(CN(CCO)CCO)cs1

ATX inhibitor 15 (compound 30) is an indole-based carbamate derivative with a strong inhibitory effect on autotaxin (ATX), demonstrated by an IC50 of 2.17 nM. Additionally, ATX inhibitor 15 effectively inhibits ATX activity in vivo and suppresses the expression of pro-fibrotic genes. Furthermore, ATX inhibitor 15 exhibits protective effects in lung fibrosis induced by Bleomycin in mice [1].

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