Name: γ-Secretase modulator 12
Rating: 5 (10 reviews)

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HIT ID:HIT214434088
Cas No:2204249-82-9
常用名:γ-Secretase modulator 12
IUPAC:5-[8-(benzyloxy)-2-methylimidazo[1,2-a]pyridin-3-yl]-2-ethyl-2,3-dihydro-1H-isoindol-1-one
IUPAC:5-[8-(benzyloxy)-2-methylimidazo[1,2-a]pyridin-3-yl]-2-ethyl-2,3-dihydro-1H-isoindol-1-one
InChI key:BNQOGECWBFADFA-UHFFFAOYSA-N

分子式:C25H23N3O2
分子量:397.478
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CCN1Cc2cc(ccc2C1=O)-c1c(C)nc2c(OCc3ccccc3)cccn12
SMILES:CCN1Cc2cc(ccc2C1=O)-c1c(C)nc2c(OCc3ccccc3)cccn12

γ-Secretase modulator 12 (Compound 1a) is a selective compound that effectively reduces amyloid-β42 (Aβ42) levels with an IC50 of 0.39 μM. It is specifically designed for Alzheimer's disease research. Notably, γ-Secretase modulator 12 exhibits a favorable brain/plasma ratio (Kp, brain = 0.72) in mice [1].

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