Name: TYK2-IN-11
Rating: 5 (10 reviews)

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HIT ID:HIT214434190
Cas No:2757009-40-6
常用名:TYK2-IN-11
IUPAC:N-{4'-[(6-methanesulfonylpyridin-2-yl)amino]-[2,3'-bipyridin]-6'-yl}acetamide
IUPAC:N-{4'-[(6-methanesulfonylpyridin-2-yl)amino]-[2,3'-bipyridin]-6'-yl}acetamide
InChI key:SHFUHQSXZWFPTI-UHFFFAOYSA-N

分子式:C18H17N5O3S
分子量:383.43
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CC(=O)Nc1cc(Nc2cccc(n2)S(C)(=O)=O)c(cn1)-c1ccccn1
SMILES:CC(=O)Nc1cc(Nc2cccc(n2)S(C)(=O)=O)c(cn1)-c1ccccn1

TYK2-IN-11 (Compound 5B) is a potent and selective inhibitor of Tyk-2, providing inhibition to TYK2-JH2 and JAK1-JH2 with IC50 values of 0.016 nM and 0.31 nM, respectively. This compound demonstrates potential for advancing research in the area of inflammatory and autoimmune diseases [1].

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