Name: Chitin synthase inhibitor 2
Rating: 5 (10 reviews)

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HIT ID:HIT214434227
Cas No:2416338-24-2
常用名:Chitin synthase inhibitor 2
IUPAC:N'-(3-methylphenyl)-N-(2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)but-2-enediamide
IUPAC:N'-(3-methylphenyl)-N-(2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)but-2-enediamide
InChI key:IBXKKDCQPPLETQ-UHFFFAOYSA-N

分子式:C20H19N3O3
分子量:349.39
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cc1cccc(NC(=O)C=CC(=O)NC2Cc3ccccc3NC2=O)c1
SMILES:Cc1cccc(NC(=O)C=CC(=O)NC2Cc3ccccc3NC2=O)c1

Chitin synthase inhibitor 2 (compound 2b) is a highly potent inhibitor of chitin synthase, with an IC50 value of 0.09 mM and a K i value of 0.12 mM. This compound exhibits antimicrobial activities in vitro and demonstrates synergistic or additive effects when combined with fluconazole or polyoxin B [1].

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