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HIT214434283
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HIT214434283
  • HIT ID:HIT214434283
  • Cas No:2132412-77-0
  • 常用名:HIV-1 inhibitor-30
  • IUPAC:2-(1-butoxy-1H-indol-3-yl)-N-(3-chloropyridin-4-yl)acetamide
    IUPAC:2-(1-butoxy-1H-indol-3-yl)-N-(3-chloropyridin-4-yl)acetamide
  • InChI key:JPPDARPGFXISJD-UHFFFAOYSA-N
  • 分子式:C19H20ClN3O2
  • 分子量:357.84
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:CCCCOn1cc(CC(=O)Nc2ccncc2Cl)c2ccccc12
    SMILES:CCCCOn1cc(CC(=O)Nc2ccncc2Cl)c2ccccc12
  • HIV-1 inhibitor-30 (compound 10i) is a potent inhibitor of HIV-1, specifically targeting the RT DNA polymerase enzyme. It exhibits strong antiretroviral activity, with an EC 50 value of 40 nM and an IC 50 value of 80 nM. Furthermore, HIV-1 inhibitor-30 demonstrates significant effectiveness against seven NNRTI-resistant strains of HIV-1 (RT-K103N; RT-Y181C; RT-K103N, Y181C; RT-L100I, K103N; RT-Y188L; RT-K103N, G190A; RT-K103N, V108I), with IC 50 values ranging from 0.04 to 1.42 μM. This compound holds potential for AIDS research [1].
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    6-8周
    纯度
    -
    ¥ 10,600.00
    1

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