Name: ERK5-IN-4
Rating: 5 (10 reviews)

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HIT ID:HIT214434332
Cas No:1888305-17-6
常用名:ERK5-IN-4
IUPAC:4-(3,6-dichloro-2-fluorobenzoyl)-N-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrole-2-carboxamide
IUPAC:4-(3,6-dichloro-2-fluorobenzoyl)-N-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrole-2-carboxamide
InChI key:LIEUQFMVFKJKHX-UHFFFAOYSA-N

分子式:C16H11Cl2FN4O2
分子量:381.19
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cn1cc(NC(=O)c2cc(c[nH]2)C(=O)c2c(Cl)ccc(Cl)c2F)cn1
SMILES:Cn1cc(NC(=O)c2cc(c[nH]2)C(=O)c2c(Cl)ccc(Cl)c2F)cn1

ERK5-IN-4 (compound 34b) is a powerful and specific inhibitor of extracellular signal-related kinase 5 (ERK5) activity. It effectively inhibits both the full-length ERK5 and the truncated ERK5 (ERK5 ΔTAD) kinase activity in HEK293 cells with IC50 values of 77 nM and 300 nM, respectively [1].

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