Name: PTG-0861
Rating: 5 (10 reviews)

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sdf 文件

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HIT ID:HIT214434354
Cas No:2494082-34-5
常用名:PTG-0861
IUPAC:2,3,4,5,6-pentafluoro-N-{[4-(hydroxycarbamoyl)phenyl]methyl}benzamide
IUPAC:2,3,4,5,6-pentafluoro-N-{[4-(hydroxycarbamoyl)phenyl]methyl}benzamide
InChI key:KMHKOOKREYIIBC-UHFFFAOYSA-N

分子式:C15H9F5N2O3
分子量:360.24
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:ONC(=O)c1ccc(CNC(=O)c2c(F)c(F)c(F)c(F)c2F)cc1
SMILES:ONC(=O)c1ccc(CNC(=O)c2c(F)c(F)c(F)c(F)c2F)cc1

PTG-0861 is a highly specific inhibitor of histone deacetylase 6 (HDAC6), demonstrating an impressive IC50 value of 5.92 nm. This compound effectively triggers apoptosis and holds potential for research pertaining to acute myeloid leukemia, multiple myeloma, and other hematological cancers [1].

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