Name: CD73-IN-8
Rating: 5 (10 reviews)

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HIT ID:HIT214434531
Cas No:2763710-08-1
常用名:CD73-IN-8
IUPAC:5-{6-chloro-5-[(1R,2R)-2-phenylcyclopropyl]pyridazin-3-yl}-1,2,3,4-tetrahydropyrimidine-2,4-dione
IUPAC:5-{6-chloro-5-[(1R,2R)-2-phenylcyclopropyl]pyridazin-3-yl}-1,2,3,4-tetrahydropyrimidine-2,4-dione
InChI key:YPRQRHQKCLDAGB-WDEREUQCSA-N

分子式:C17H13ClN4O2
分子量:340.77
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Clc1nnc(cc1[C@@H]1C[C@H]1c1ccccc1)-c1c[nH]c(=O)[nH]c1=O
SMILES:Clc1nnc(cc1[C@@H]1C[C@H]1c1ccccc1)-c1c[nH]c(=O)[nH]c1=O

CD73-IN-8, a potent CD73 inhibitor, prevents the catalytic activity of CD73, an enzyme responsible for converting extracellular 5'-phosphate adenosine (5'-AMP) to adenosine. Adenosine, once produced, can induce immunosuppressive effects and facilitate tumor proliferation and/or metastasis. Therefore, CD73-IN-8 holds promise in the development of therapeutic interventions for tumor-related diseases[1].

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