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  3. HIT214434593
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HIT214434593
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HIT214434593
  • HIT ID:HIT214434593
  • Cas No:2241915-59-1
  • 常用名:Anticancer agent 56
  • IUPAC:(2E)-1-[1-(4-chlorophenyl)-5-methyl-1H-1,2,3-triazol-4-yl]-3-(3,4-dimethoxyphenyl)prop-2-en-1-one
    IUPAC:(2E)-1-[1-(4-chlorophenyl)-5-methyl-1H-1,2,3-triazol-4-yl]-3-(3,4-dimethoxyphenyl)prop-2-en-1-one
  • InChI key:YOJHPSLHBFFDDL-ONNFQVAWSA-N
  • 分子式:C20H18ClN3O3
  • 分子量:383.83
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:COc1ccc(\C=C\C(=O)c2nnn(c2C)-c2ccc(Cl)cc2)cc1OC
    SMILES:COc1ccc(\C=C\C(=O)c2nnn(c2C)-c2ccc(Cl)cc2)cc1OC
  • Anticancer agent 56 (compound 4d) is a powerful anti-cancer compound with favorable drug-like properties. It shows significant anticancer activity against multiple cancer cell lines, with an IC50 value of less than 3 μM. Anticancer agent 56 exerts its effects by causing cell cycle arrest at the G2/M phase and activating the mitochondrial apoptosis pathway. Mechanistically, it induces the accumulation of reactive oxygen species (ROS), upregulates BAX, downregulates Bcl-2, and triggers the activation of caspases 3, 7, and 9 [1].
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    6-8周
    纯度
    -
    ¥ 10,600.00
    1

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