ALK5-IN-8 | CAS 2705900-81-6 | AnyMole

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HIT214434831

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HIT214434831

HIT ID:HIT214434831
Cas No:2705900-81-6
常用名:ALK5-IN-8
IUPAC:ethyl 5-[3-(4-fluorophenyl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyridine-3-carboxylate
IUPAC:ethyl 5-[3-(4-fluorophenyl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyridine-3-carboxylate
InChI key:GFFVSPZTWRNCIU-UHFFFAOYSA-N

分子式:C19H15FN4O2
分子量:350.353
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CCOC(=O)c1cnn2ccc(cc12)-c1c[nH]nc1-c1ccc(F)cc1
SMILES:CCOC(=O)c1cnn2ccc(cc12)-c1c[nH]nc1-c1ccc(F)cc1

ALK5-IN-8 is a highly effective inhibitor of TGFβRI (ALK5). It hinders the phosphorylation of ALK5 on downstream signaling proteins (Smad2 or Smad3) by obstructing the interaction between TGFβRI and ligands. Consequently, it disrupts or prevents TGF-β signaling. ALK5-IN-8 shows promise in the study of diverse diseases associated with ALK5-mediated pathways[1].

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TargetMolSC
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5日内发货
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-
¥ 1,600.00
1

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