Name: TGFβ-IN-2
Rating: 5 (10 reviews)

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HIT ID:HIT214434880
Cas No:2387678-02-4
常用名:TGFβ-IN-2
IUPAC:N-{4-[(2-oxo-2H-chromen-4-yl)oxy]phenyl}-2-(piperidin-1-yl)acetamide
IUPAC:N-{4-[(2-oxo-2H-chromen-4-yl)oxy]phenyl}-2-(piperidin-1-yl)acetamide
InChI key:PHLACHIKRYAJCZ-UHFFFAOYSA-N

分子式:C22H22N2O4
分子量:378.428
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:O=C(CN1CCCCC1)Nc1ccc(Oc2cc(=O)oc3ccccc23)cc1
SMILES:O=C(CN1CCCCC1)Nc1ccc(Oc2cc(=O)oc3ccccc23)cc1

TGFβ-IN-2 (Compound 9d) effectively inhibits the accumulation of total collagen induced by TGF-β in NRK-49F cells, with an IC 50 value of 4.31 μM. It also suppresses the in vitro protein expression of COL1A1, α-SMA, and p-Smad3, which are induced by TGF-β. Additionally, TGFβ-IN-2 shows promise as a potential anti-fibrosis compound for in vivo applications through oral administration [1].

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