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  3. HIT214435013
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HIT214435013
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HIT214435013
  • HIT ID:HIT214435013
  • Cas No:2761366-60-1
  • 常用名:BRD4 Inhibitor-15
  • IUPAC:5-(1-benzyl-1H-indazol-6-yl)-4-ethoxy-1-methyl-1,2-dihydropyridin-2-one
    IUPAC:5-(1-benzyl-1H-indazol-6-yl)-4-ethoxy-1-methyl-1,2-dihydropyridin-2-one
  • InChI key:GWTFQNZDRCSCTL-UHFFFAOYSA-N
  • 分子式:C22H21N3O2
  • 分子量:359.429
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:CCOc1cc(=O)n(C)cc1-c1ccc2cnn(Cc3ccccc3)c2c1
    SMILES:CCOc1cc(=O)n(C)cc1-c1ccc2cnn(Cc3ccccc3)c2c1
  • BRD4 Inhibitor-15 (compound 13) is a highly potent and specific inhibitor of BRD4, effectively inhibiting it with an IC50 of 18 nM. By regulating the Bcl-2/Bax proteins and activating the caspase-3 signaling pathway, BRD4 Inhibitor-15 induces apoptosis of 22RV1 cells. Additionally, it effectively down-regulates the c-Myc level in 22RV1 cells. Due to its properties, BRD4 Inhibitor-15 is a valuable compound for research related to prostate cancer [1].
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  • 供应商
    TargetMolSC
    规格
    货期
    6-8周
    纯度
    -
    ¥ 14,900.00
    1

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