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- HIT ID:HIT214435017
- Cas No:184576-87-2
- 常用名:ROS 234
- InChI key:XAJKXTPKZFCYPN-UHFFFAOYSA-N
- 分子式:C13H15N5
- 分子量:241.298
- 氢键供体数 (HBD):
- 氢键受体数 (HBA):
- LogP:
- ROS 234 is a highly effective H3 antagonist, demonstrating a strong binding affinity (pK B) of 9.46 for the Guinea-pig ileum H3 receptor and a pKi of 8.90 for the Rat cerebral cortex H3 receptor. Additionally, it exhibits an ex vivo ED50 of 19.12 mg/kg (ip) in the Rat cerebral cortex. It should be noted that ROS 234 demonstrates limited central access, as reported in [1] and [2].
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