Name: HDAC6-IN-10
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT214435043
Cas No:2408286-73-5
常用名:HDAC6-IN-10
IUPAC:N-hydroxy-4-{[(3R)-3-[(1H-indol-3-yl)methyl]-2,5-dioxopiperazin-1-yl]methyl}benzamide
IUPAC:N-hydroxy-4-{[(3R)-3-[(1H-indol-3-yl)methyl]-2,5-dioxopiperazin-1-yl]methyl}benzamide
InChI key:OUWQFNHQQZCXTJ-GOSISDBHSA-N

分子式:C21H20N4O4
分子量:392.415
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:ONC(=O)c1ccc(CN2CC(=O)N[C@H](Cc3c[nH]c4ccccc34)C2=O)cc1
SMILES:ONC(=O)c1ccc(CN2CC(=O)N[C@H](Cc3c[nH]c4ccccc34)C2=O)cc1

HDAC6-IN-10 is a potent and specific HDAC6 inhibitor, exhibiting an IC50 value of 0.73 nM. It demonstrates remarkable selectivity towards HDAC6, with a selectivity range of 144 to 10,941-fold over other HDAC isoforms. Furthermore, HDAC6-IN-10 exhibits notable anti-proliferative effects on multiple myeloma cells [1].

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