Name: Topoisomerase I inhibitor 4
Rating: 5 (10 reviews)

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HIT ID:HIT214435139
Cas No:2485135-31-5
常用名:Topoisomerase I inhibitor 4
IUPAC:7-fluoro-6-(piperazin-1-yl)-3,11-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2,4,6,8,13,15,17,19-nonaen-10-one
IUPAC:7-fluoro-6-(piperazin-1-yl)-3,11-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2,4,6,8,13,15,17,19-nonaen-10-one
InChI key:LCHXXXKCDTVPMB-UHFFFAOYSA-N

分子式:C23H19FN4O
分子量:386.43
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Fc1cc2c(cc1N1CCNCC1)nc1-c3cc4ccccc4cc3Cn1c2=O
SMILES:Fc1cc2c(cc1N1CCNCC1)nc1-c3cc4ccccc4cc3Cn1c2=O

Topoisomerase I inhibitor 4 (compound 7a) is a potent inhibitor of topoisomerase I activity. It effectively inhibits the proliferation of various cancer cell lines including HepG2, A549, MCF-7, and HeLa, with IC50 values of 1.20 μM, 2.09 μM, 1.56 μM, and 1.92 μM, respectively. Thus, Topoisomerase I inhibitor 4 holds promise for cancer research applications [1].

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