Name: SSTR4 agonist 3
Rating: 5 (10 reviews)

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HIT ID:HIT214435245
Cas No:2744188-34-7
常用名:SSTR4 agonist 3
IUPAC:(1R,5S,6R)-N-{2-[1-methyl-7-(methylsulfanyl)-1H-indazol-3-yl]propan-2-yl}-3-azabicyclo[3.1.0]hexane-6-carboxamide
IUPAC:(1R,5S,6R)-N-{2-[1-methyl-7-(methylsulfanyl)-1H-indazol-3-yl]propan-2-yl}-3-azabicyclo[3.1.0]hexane-6-carboxamide
InChI key:ZSJOTBMEVCKPRD-IMRBUKKESA-N

分子式:C18H24N4OS
分子量:344.48
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[H][C@@]12CNC[C@]1([H])[C@H]2C(=O)NC(C)(C)c1nn(C)c2c(SC)cccc12
SMILES:[H][C@@]12CNC[C@]1([H])[C@H]2C(=O)NC(C)(C)c1nn(C)c2c(SC)cccc12

SSTR4 agonist 3 is a potent compound that activates the SSTR4 receptor. The SSTR4 receptor is highly expressed in the hippocampus and neocortex, which are regions associated with memory, learning, and Alzheimer's disease pathology. SSTR4 agonists demonstrate strong efficacy in rodent models of pain, both acute and chronic, by reducing peripheral nociception and inflammation. Considering its potential application in pain research, SSTR4 agonist 3 is of interest[1].

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