Name: BF844
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT214435259
Cas No:1404506-35-9
常用名:BF844
IUPAC:1-{4-chloro-3,5-diphenyl-1H-pyrazolo[3,4-c]pyridazin-1-yl}-2-methylpropan-2-ol
IUPAC:1-{4-chloro-3,5-diphenyl-1H-pyrazolo[3,4-c]pyridazin-1-yl}-2-methylpropan-2-ol
InChI key:TVNSCKMVODVWRS-UHFFFAOYSA-N

分子式:C21H19ClN4O
分子量:378.86
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CC(C)(O)Cn1nc(-c2ccccc2)c2c(Cl)c(nnc12)-c1ccccc1
SMILES:CC(C)(O)Cn1nc(-c2ccccc2)c2c(Cl)c(nnc12)-c1ccccc1

BF844 is a chemical compound that demonstrates the ability to mitigate hearing loss in individuals with Usher Syndrome Type III (USH3) caused by the CLRN1 mutation (specifically N48K). One of its mechanisms of action is the transportation of CLRN1 N48K to the plasma membrane. In vivo studies have shown that BF844 significantly preserves hearing [1].

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