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  3. HIT214435287
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HIT214435287
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HIT214435287
  • HIT ID:HIT214435287
  • Cas No:27060-70-4
  • 常用名:Pentagamavunon-1
  • IUPAC:2,5-bis[(4-hydroxy-3,5-dimethylphenyl)methylidene]cyclopentan-1-one
    IUPAC:2,5-bis[(4-hydroxy-3,5-dimethylphenyl)methylidene]cyclopentan-1-one
  • InChI key:OHSKJRMWVIVJCP-UHFFFAOYSA-N
  • 分子式:C23H24O3
  • 分子量:348.442
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:Cc1cc(C=C2CCC(=Cc3cc(C)c(O)c(C)c3)C2=O)cc(C)c1O
    SMILES:Cc1cc(C=C2CCC(=Cc3cc(C)c(O)c(C)c3)C2=O)cc(C)c1O
  • Pentagamavunon-1 (PGV-1) is an oral Curcumin analog that effectively induces apoptosis through multiple molecular mechanisms. It primarily targets and inhibits key angiogenic factors, including cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF), which play crucial roles in mediating cell proliferation and survival. Additionally, PGV-1 possesses the ability to inhibit the activation of NF-κB, further enhancing its apoptotic effects. [1]
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  • 供应商
    TargetMolSC
    规格
    货期
    5日内发货
    纯度
    -
    ¥ 295.00
    1

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