Name: IRAK4-IN-17
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT214435370
Cas No:2183503-33-3
常用名:IRAK4-IN-17
IUPAC:N-[3-(difluoromethyl)-1-methyl-1H-pyrazol-4-yl]-6-{[(3R)-piperidin-3-yl]amino}imidazo[1,2-b]pyridazine-3-carboxamide
IUPAC:N-[3-(difluoromethyl)-1-methyl-1H-pyrazol-4-yl]-6-{[(3R)-piperidin-3-yl]amino}imidazo[1,2-b]pyridazine-3-carboxamide
InChI key:UEBUQGYHDQFQRH-SNVBAGLBSA-N

分子式:C17H20F2N8O
分子量:390.399
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cn1cc(NC(=O)c2cnc3ccc(N[C@@H]4CCCNC4)nn23)c(n1)C(F)F
SMILES:Cn1cc(NC(=O)c2cnc3ccc(N[C@@H]4CCCNC4)nn23)c(n1)C(F)F

IRAK4-IN-17 (Compound 5) is a highly potent inhibitor of IRAK4, exhibiting an impressive IC50 value of 1.3 nM [1]. This compound is particularly valuable for research focused on large B-cell lymphoma (DLBCL) [1].

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