Name: Aldose reductase-IN-6
Rating: 5 (10 reviews)

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HIT ID:HIT214435390
Cas No:2470019-41-9
常用名:Aldose reductase-IN-6
IUPAC:4-(2-{2-[(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)methylidene]hydrazin-1-yl}-1,3-thiazol-4-yl)benzonitrile
IUPAC:4-(2-{2-[(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)methylidene]hydrazin-1-yl}-1,3-thiazol-4-yl)benzonitrile
InChI key:JGTBCKRXHWTUDP-UHFFFAOYSA-N

分子式:C20H16N4O2S
分子量:376.43
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:N#Cc1ccc(cc1)-c1csc(NN=Cc2ccc3OCCCOc3c2)n1
SMILES:N#Cc1ccc(cc1)-c1csc(NN=Cc2ccc3OCCCOc3c2)n1

Aldose reductase-IN-6 (Compound 3) is a competitive inhibitor of aldose reductase (AR), possessing an IC50 of 3.164 μM and a Ki of 0.018 μM. Notably, Aldose reductase-IN-6 demonstrates no cytotoxicity toward normal cells [1].

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