Name: hCAI/II-IN-2
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT214435398
Cas No:2480283-75-6
常用名:hCAI/II-IN-2
IUPAC:ethyl 5-(4-sulfamoylbenzamido)-1,3,4-thiadiazole-2-carboxylate
IUPAC:ethyl 5-(4-sulfamoylbenzamido)-1,3,4-thiadiazole-2-carboxylate
InChI key:HRSGBOLVGNUHSW-UHFFFAOYSA-N

分子式:C12H12N4O5S2
分子量:356.37
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CCOC(=O)c1nnc(NC(=O)c2ccc(cc2)S(N)(=O)=O)s1
SMILES:CCOC(=O)c1nnc(NC(=O)c2ccc(cc2)S(N)(=O)=O)s1

hCAI/II-IN-2 (compound 2b) is a highly effective dual inhibitor of human carbonic anhydrase I and II (hCA I/II), with Ki values of 40.97 nM, 15.15 nM, and 61.88 nM for hCA I, hCA II, and hCA IX, respectively. With its anti-hypoxic properties, hCAI/II-IN-2 demonstrates activity against acute mountain sickness (AMS). Furthermore, this compound exhibits low cellular activity [1].

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