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  3. HIT214435449
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HIT214435449
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HIT214435449
  • HIT ID:HIT214435449
  • Cas No:2413974-53-3
  • 常用名:Mt KARI-IN-4
  • IUPAC:1-(4-fluorophenyl)-3-[5-(5-nitrofuran-2-yl)-1,3,4-thiadiazol-2-yl]thiourea
    IUPAC:1-(4-fluorophenyl)-3-[5-(5-nitrofuran-2-yl)-1,3,4-thiadiazol-2-yl]thiourea
  • InChI key:HDQHMZWYSJUDQT-UHFFFAOYSA-N
  • 分子式:C13H8FN5O3S2
  • 分子量:365.36
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:[O-][N+](=O)c1ccc(o1)-c1nnc(NC(=S)Nc2ccc(F)cc2)s1
    SMILES:[O-][N+](=O)c1ccc(o1)-c1nnc(NC(=S)Nc2ccc(F)cc2)s1
  • Mt KARI-IN-4 (compound 5c) is a highly effective inhibitor of Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI), demonstrating a Ki value of 5.48 μM. Additionally, Mt KARI-IN-4 displays inhibitory properties against Mtb H37Rv, with a minimum inhibitory concentration (MIC) of 0.78 μM. Importantly, this compound exhibits low levels of cytotoxicity, as evident from its half-maximal inhibitory concentration (IC 50 ) value of over 72 μg/mL against human embryonic kidney cells (HEK) [1].
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    6-8周
    纯度
    -
    ¥ 10,600.00
    1

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