Name: L-I-OddU
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT214435492
Cas No:207920-87-4
常用名:L-I-OddU
IUPAC:1-[(2S,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl]-5-iodo-1,2,3,4-tetrahydropyrimidine-2,4-dione
IUPAC:1-[(2S,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl]-5-iodo-1,2,3,4-tetrahydropyrimidine-2,4-dione
InChI key:GFRQBEMRUYIKAQ-WDSKDSINSA-N

分子式:C8H9IN2O5
分子量:340.073
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:OC[C@H]1OC[C@H](O1)n1cc(I)c(=O)[nH]c1=O
SMILES:OC[C@H]1OC[C@H](O1)n1cc(I)c(=O)[nH]c1=O

L-I-OddU, a potent and selective anti-Epstein-Barr virus (EBV) agent, is a L-5'-halo-dioxolane nucleoside analogue. It demonstrates antiviral activity by effectively suppressing replicative EBV DNA and viral protein synthesis [1] [2]. With an EC 50 value of 0.03 μM, L-I-OddU exhibits high potency against EBV while maintaining low cytotoxicity, as indicated by its CC 50 value of 1000 nM.

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