ATR-IN-14 | CAS 2765785-88-2 | AnyMole

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HIT214435564

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HIT214435564

HIT ID:HIT214435564
Cas No:2765785-88-2
常用名:ATR-IN-14
IUPAC:5-fluoro-4-(1-methyl-1H-pyrazol-5-yl)-2-[(3R)-3-methylmorpholin-4-yl]-8-(1H-pyrazol-3-yl)-1,7-naphthyridine
IUPAC:5-fluoro-4-(1-methyl-1H-pyrazol-5-yl)-2-[(3R)-3-methylmorpholin-4-yl]-8-(1H-pyrazol-3-yl)-1,7-naphthyridine
InChI key:DWIFLVFTZABWNK-GFCCVEGCSA-N

分子式:C20H20FN7O
分子量:393.426
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:C[C@@H]1COCCN1c1cc(-c2ccnn2C)c2c(F)cnc(-c3cc[nH]n3)c2n1
SMILES:C[C@@H]1COCCN1c1cc(-c2ccnn2C)c2c(F)cnc(-c3cc[nH]n3)c2n1

ATR-IN-14 (compound 1) is a powerful ATR kinase inhibitor that significantly inhibits ATR signaling pathways following CHKI protein phosphorylation, demonstrating a remarkable inhibition rate of 98.03% at 25 nM. Moreover, ATR-IN-14 exhibits notable anticancer efficacy in LoVo cells, displaying an IC50 value of 64 nM [1].

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TargetMolSC
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货期
10-14周
纯度
-
¥ 10,600.00
1

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