Topoisomerase II inhibitor 3 | CAS 99140-25-7 | AnyMole

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HIT214435639

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HIT214435639

HIT ID:HIT214435639
Cas No:99140-25-7
常用名:Topoisomerase II inhibitor 3
IUPAC:1-{[3-(dimethylamino)propyl]amino}-7-hydroxy-4-nitro-9,10-dihydroacridin-9-one
IUPAC:1-{[3-(dimethylamino)propyl]amino}-7-hydroxy-4-nitro-9,10-dihydroacridin-9-one
InChI key:VNSZLRBNUNIGRI-UHFFFAOYSA-N

分子式:C18H20N4O4
分子量:356.382
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CN(C)CCCNc1ccc([N+]([O-])=O)c2[nH]c3ccc(O)cc3c(=O)c12
SMILES:CN(C)CCCNc1ccc([N+]([O-])=O)c2[nH]c3ccc(O)cc3c(=O)c12

Topoisomerase II inhibitor 3 (Compound 6 h) is an acridone derivative that acts as a Type II DNA topoisomerase (topo II) inhibitor. It specifically inhibits the topo IIα/β subtypes, with an IC50 value of 0.17 μM for topo IIα and 0.23 μM for topo IIβ. This compound elicits significant DNA damage and induces apoptosis by triggering the loss of mitochondrial membrane potential [1].

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TargetMolSC
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货期
6-8周
纯度
-
¥ 10,600.00
1

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