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  3. HIT214435677
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HIT214435677
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HIT214435677
  • HIT ID:HIT214435677
  • Cas No:2230218-36-5
  • 常用名:D18
  • IUPAC:N4-butyl-6-({4-[(dimethylamino)methyl]phenyl}methyl)pyrido[3,2-d]pyrimidine-2,4-diamine
    IUPAC:N4-butyl-6-({4-[(dimethylamino)methyl]phenyl}methyl)pyrido[3,2-d]pyrimidine-2,4-diamine
  • InChI key:DUCCCPVHDPRCEB-UHFFFAOYSA-N
  • 分子式:C21H28N6
  • 分子量:364.497
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:CCCCNc1nc(N)nc2ccc(Cc3ccc(CN(C)C)cc3)nc12
    SMILES:CCCCNc1nc(N)nc2ccc(Cc3ccc(CN(C)C)cc3)nc12
  • D18 is an immune modulator that acts as a dual agonist for TLR7/8 (with EC50 values of 24 nM for hTLR7 and 10 nM for hTLR8, respectively). It enhances the expression of PD-L1 through epigenetic regulation, thereby increasing the sensitivity of tumors to PD-1/PD-L1 blockade. Additionally, D18 functions as a cytotoxin for ADC synthesis, specifically for the ADC HE-S2 [1].
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    10-14周
    纯度
    -
    ¥ 10,600.00
    1

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