Name: Aβ-IN-5
Rating: 5 (10 reviews)

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sdf 文件

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类似物检索

HIT ID:HIT214435701
Cas No:2417977-65-0
常用名:Aβ-IN-5
IUPAC:(2E)-3-(3,4-dihydroxyphenyl)-1-{1-methyl-1H,2H,3H,4H,9H-pyrido[3,4-b]indol-2-yl}prop-2-en-1-one
IUPAC:(2E)-3-(3,4-dihydroxyphenyl)-1-{1-methyl-1H,2H,3H,4H,9H-pyrido[3,4-b]indol-2-yl}prop-2-en-1-one
InChI key:DVNRFULMEKPACO-VQHVLOKHSA-N

分子式:C21H20N2O3
分子量:348.402
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CC1N(CCc2c1[nH]c1ccccc21)C(=O)\C=C\c1ccc(O)c(O)c1
SMILES:CC1N(CCc2c1[nH]c1ccccc21)C(=O)\C=C\c1ccc(O)c(O)c1

Aβ-IN-5 (Compound e12) is an orally active Aβ aggregation inhibitor that also inhibits AChE and BuChE with IC50 values of 21.29 μM and 1.32 μM, respectively. Furthermore, Aβ-IN-5 exhibits remarkable neuroprotective effects along with low neurotoxicity [1].

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